prazosin

Prazosin-One of the highly effective drugs used to treat hypertension. It is used readily these days especially with many troops being diagnosed with PTSD.
 * 1) NHCSNH2,HCL
 * 2) Dimethyl sulphate,NAOH
 * 3) unhydrous piperazine,isopropyl alcohol
 * 4) 2-furoyl chloride,isopropyl alcohol,potassium carbonate,TEBA chlroide
 * 5) POCl,isopropyl alcohol
 * 6) NH3,THF 0-5%

Synthesis and indentification of the major meatbolites of prazosin-Althius TS, Hess HJ. Creation of New Drugs-1988 Plenum Publishing corporation(article) Development of highly yeild synthetic process for Prazosin1Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur - 425 405, Dhule, Maharashtra, India

Lydia Owusu-Tweneboah Elein Ravelo

This is a good find with some interesting chemistry. What I find especially interesting are the acid catalyzed addition of thiourea into 2-amino benzoate function and the displacement of the methyl thio ether group by piperidine. Can you comment on the steps in this sequence thinking of electron flow, and why they work thermodynamically? Bruce Bondurant



The synthetic chemistry has went through sequential processes with nitriles and amines starting from the first initial untraceable cleavage and cyclization. Also Quinazolines are rare but found within this synthesis that help block alpha activities. These aid in the relief of post traumatic stress disorder, by behaving as an relaxant to calm the nerve endings within the brain that control the subconscious mind.

Protective Groups in Organic Synthesis Green, Theodora 1931-2005 New York; Wiley c1999

Jeffrey Asphall/ Jeffrey Dujuste -CHMFALL2010

I like the discussion of the physiological effects, but I don't follow the synthetic scheme or the description. The ortho amination of the aryl thioisocyanate and the conversion to a methyl group and then to an amide are reactions that I have never heard of. I know they are not in Grene, because I have read that book. Where did you find them? Bruce Bondurant

Sorry about that we look for information several books but we thought the information we produced came from that book but we also look at these books too

1. //Modern Pharmacology with Clinical Applications// Craig, Charles R, and Robert E. Stitzel. . Boston: Little, Brown, 1997. 2. //Principles and Practice of Dialysis// Henrich, William L.. Baltimore: Williams & Wilkins, 1994. 3. //The Chemistry of Heterocycles: Structure, Reactions, Syntheses, and Applications//. Eicher, Theophil, Siegfried Hauptmann, and Andreas Speicher. Weinheim: Wiley-VCH, 2003 OK I will look them up Bruce Bondurant