atropine

Katalin: I like the double michael addition strategy to make the bridged system, At first I was skeptical that th e cyclohept-2,6-dienone could be purchased through Aldrich, but It was there, though the price ($60/mg) is a little steep. From the reactions that we have just discussed in class, can you think of how this starting material could possibly be made with acetone and succinaldehyde? Bruce Bondurant

Would this work -- Saleel : Yes, This is a workable route into the side chain. Bromine may be more selective for the free radical benzylic halogenation, but the strategy makes good sense. just write up a paragraph describing these steps, and this one is done. Bruce Bondurant