thyroxine



During the rearrangement, the mechanism of which is not fully elucidated, epoxide intermediates are likely to form. Note that all reaction steps are catalyzed by the thyroid specific peroxidase. Some background information about thyroxine is that it is the main hormone produced by the thyroid gland. Also, thyroxine plays a vital role in regulating many of the body’s metabolic functions. Thyroxine also play a role is chemical imbalances in the body for example the condition called hypothyroidism, which is caused from under-production of thyroxine by the thyroid gland. This occurs either because the gland is naturally underactive or because radioiodine therapy or surgery for an overactive gland has resulted in under activity. Thyroxine is take to replace the deficiency which exists in such situations and therefore to restore normal metabolic activity. ** Jeffrey Dujuste / Jeffrey Asphall **


 * Greene, Theodora W, and Peter G. M. Wuts. //Protective Groups in Organic Synthesis//. New York: Wiley, 1999. Internet resource.

This bio synthesis is interesting. The iodination reactions make perfect sense from a synthetic point of view. they could be achieved easily with iodin and nitric acid. The cleavage of a carbon carbon bond to form an ether in the last step is totally amazing. I dont understand how this works, and neither does anyone else, according to your writup. Can you think of any way that you might make this compound from, for example , 4-fluoro-1-nitro benzene and your second intermediate? Bruce Bondurant