kinoprene



To get started on this look up 5-methyl-2-hexanone Sigma Aldrich product number 537705 It's cheap, and I bet you could fanagle it into the branched acid.



- The starting material to be used is found in the Sigma Aldrich website catalog, product # 186597 and it is a 95% mix of //cis// and //trans// "**Dimethyl 3-Methylglutaconate**" with a linear formula of: CH3-O2-CCH2-C(CH3)=CH-CO2-CH3 (I don't know if $164 for 10g of this compound is cheap though) - A company in California, Zoecon Corp, makes a compund available for commercial use, an aldehyde: "**3,7-dimethyl octaldehyde**" - Zoeon Corp has provided me with the initial synthesis, using this aldehyde reacting with the starting material from Sigma Aldrich. - DMF is a polar solvent that Zoecon Corp uses. The SOCL2 (Thionyl Chloride) replaces the hydroxy from the carboxyllic acid with the Chlorine in order to prepare to react with the alkynalcohol. I used the **Fisher Esterification** process using the propane-2-yl-1-ol in the last step of synthesis. Fisher esterification is with an alcohol and an acid - Having completed Chapter 22 has been very useful, to me, in understanding the mechanisms of alpha-substitution/ alpha-carbon condensation chemistry. - The end product is finally made after 8 steps, involving Kinetic and Thermal reactions, fisher esterification process, condensation reaction into 1 Nucleophile of an aldehyde where the dimethyl pyridine acts as a mild base... solvent is Toluene. The NaOCH3 in Ch3OH is to restore at least 1 acidic group. With the carboxylic acid, the //cis// isomer the catalyst Benzenethiol from (Z) to (E)-finally I learned how to use Tautomerization chemistry!!!

This is fantastic, nice description Bruce Bondurant

Dr. Bondurant, I agree with the mechanism that Johnny has proposed. We worked together on it, and you told us we had comment to get credit for it. He really helped me out by figuring out the last step of the synthesis which was Fisher Esterification, which gave us the final product: Kinoprene. Carlos Avila